| ¢º Special Lectures | ¢º Presidential Lecture | ||
Plenary Lectures
May 16 (Thursday) Lecture Hall A
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PL1 |
11:40¡12:30 |
Chair Myeong-Hee Yu, KIST |
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Structural Biology of Prion Proteins
Using NMR and the Mad Cow Crisis Dr. Kurt Wüthrich (ETH Zürich, Switzerland) |
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PL2 |
13:50¡14:40 |
Chair Young-Myeong Kim, Kangwon National Univ. |
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Role of Laminin-1 in Metastasis and
Angiogenesis Dr. Hynda K. Kleinman (National Institute of Dental and Craniofacial Research, U.S.A.) |
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May 17 (Friday) Lecture Hall A
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PL3 |
11:40¡12:30 |
Chair Yu Sam Kim, Yonsei Univ. |
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The Neurobiology of Synaptic Transmission
Dr. Paul Greengard (The Rockefeller University, U.S.A.) |
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Dr. Kurt Wuthrich ETH Z rich, Switzerland
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Kurt Wuthrich was born in Switzerland on October 4,1938. He obtained his Ph.D. in inorganic chemistry at the University of Basel in 1964. Since 1969, he served as a Professor of Biophysics at ETH Zrich. Since 2001 he shares his time between the ETH Z rich and Scripps Research Institute, where he is currently the Cecil H. and Ida M. Green Visiting Professor of Structural Biology. His specialty is high resolution nuclear magnetic resonance (NMR) spectroscopy with biological macromolecules. W thrich's contributions to techniques development include the NMR method for three dimensional structure determination of protein and nucleic acids in solution. The W thrich group has solved more than 50 NMR structures of proteins and nucleic acids, including the cyclophilin A-cycloporin A, and prion proteins. W thrich's bibliography includes over 600 papers and reviews. Prion proteins (PrP) have become a major research focus of the W thrich laboratory since 1994, which resulted in the first three-dimensional structure obtained for this class of proteins in 1996 and subsequent structure determinations of a selected group of mammalian and non-mammalian prion proteins, including those from man, cattle and chicken, which now provide a framework for continued investigations of molecular aspects of the onset and interspecies transmission of transmissible spongiform encephalopathies. |
Dr. Hynda K. Kleinman National Institute of Dental and Craniofacial Research, U.S.A.
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Hynda K. Kleinman was graduated from Simmons College in 1969 and received an MS in chemistry and a Ph.D in biochemistry from Massachusetts Institute of Technology in 1971 and 1974, respectively. She was a postdoctoral fellow at Tufts University from 1973-1975 and went to the NIH in 1975 and has been at NIDCR until the present. She is currently the Chief of the Cell Biology Section at the National Institute of Dental and Craniofacial Research. Dr. Kleinmans research focuses on the extracellular matrix in development and disease with emphasis on cell adhesion, migration, growth, and differentiation. She studies the mechanisms of tumor metastases, angiogenesis, and salivary gland cell differentiation. She has published over 300 research papers and holds 9 patents. She and colleagues were the first to show that laminin promoted neurite outgrowth and she is a co-inventor for Matrigel and the Matrigel invasion assay. She has received numerous national and international awards, including two international awards: the Hildegard Doerenkamp-Gerhardt Zbinden Award with her NIH colleagues in 1986 for developing an in vitro assay for screening anti cancer compounds which spares animals and the Debio Peptide Award in 1992 for identifying a cancer inhibiting peptide. She received the Senior Woman in Science Award in 1991 from the American Society for Cell Biology. She was elected to AAAS as a Fellow in 2001. Dr. Kleinman is on journal editorial boards, including the Cancer Research, The International Journal of Biochemistry & Cell Biology, Clinical Cancer Research, FASEB J, Journal of Cell Biology, International journal of Oncology, Angiognenesis, and Endothelium. |
Dr. Paul Greengard The Rockefeller University, U.S.A.
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Dr. Paul Greengard is the Vincent Astor Professor of Molecular and Cellular Neuroscience at The Rockefeller University, Director of The Fisher Center for Alzheimer's Research and author of over 1000 scientific publications. He began his exploration of nerve cells in 1948 when he joined the Johns Hopkins biophysics laboratory then headed by pioneering neurobiologist Detlev Bronk. After receiving his Ph.D. from Johns Hopkins in 1953, Greengard spent five years in England receiving advanced training in brain biochemistry at the University of London, at Cambridge University, and at the National Institute of Medical Research. While in England, Greengard made important findings about the biochemical regulation of the physiological functioning of brain cells. Upon his return to the United States, Greengard worked as Director of the Department of Biochemistry at Geigy Research aboratories, in Ardsley, New York for eight years. In 1967, he left the pharmaceutical industry to return to academia. He spent one year as Visiting Professor at Albert Einstein College of Medicine and Vanderbilt University School of Medicine. Greengard served as Professor of Pharmacology and Psychiatry at Yale University from 1968 to 1983 and as Professor and Head of the Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University from 1983 to the present. He has remained intensely interested in the applications of basic scientific knowledge to the development of therapeutic agents for treatment of various neurological and psychiatric diseases. Greengards discoveries have provided a conceptual framework for understanding how the nervous system functions at the molecular level. He also has demonstrated that many effects both therapeutic and toxic of several classes of common antipsychotic, hallucinogenic and antidepressant drugs can be explained in terms of distinct neurochemical actions that affect the transmission of nerve signals in the brain, a process called signal transduction. Over the past 30 years, Greengard and his colleagues have developed a general model that provides a rational explanation, at the molecular and cellular levels, of the mechanism by which stimuli both electrical and chemical produce physiological responses in individual nerve cells. Over the years, Greengards achievements have earned him many distinguished awards including the Metropolitan Life Foundation Award for Medical Research, The Charles A. Dana Award for Pioneering Achievements in Health, the Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience, The National Academy of Sciences Award in the Neurosciences, the Bristol-Myers Award for Distinguished Achievement in Neuroscience Research, the 3M Life Sciences Award of the Federation of American Societies for Experimental Biology. In the year 2000, Greengard was awarded the Nobel Prize in Physiology or Medicine for his discovery of how dopamine and several other transmitters in the brain exert their action in the nervous system. |
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Special Lectures
May 16 (Thursday) Lecture Hall B
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SL1 |
14:40¡15:20 |
Chair Seung Up Kim, Ajou Univ. |
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Cell Biology of Interneuronal Synaptic
Connections Dr. Masatoshi Takeichi (RIKEN Center for Developmental Biology, Japan) |
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May 17 (Friday) Lecture Hall B
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SL2 |
13:50¡14:40 |
Chair Jeongbin Yim, Seoul National Univ. |
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Sepiapterin Reductase Deficiency, Alternative
Pathways in Tetrahydrobio- pterin Metabolism, and Possible Impact
to The Neuronal Cell Dysfunction Dr. Nenad Blau (University Children's Hospital, Switzerland) |
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Dr. Masatoshi Takeichi RIKEN Center for Developmental Biology, Japan
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Dr. Takeichi has held a faculty position at Kyoto University for past thirty years until he recently joined RIKEN. He received doctoral degree in Kyoto University in 1973 and used to work with Dr. Richard Pagano at Carneigie Institution between 1974-1976 as a research fellow. Dr. Takeichi has received numerous prizes for his contribution to neuroscience, including Japan Academy Prize and served as an associate editor of Neuron and served as an editorial board for numerous distinguished journals including Cell and Genes & Developement. |
Dr. Nenad Blau University Children's Hospital, Switzerland
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Dr. Nenad Blau was born in 1946 in Zagreb, Croatia. After his diploma in Organic Chemistry at the University of Zagreb he spent seven years at the University Hospital in Zurich working in Clinical Chemistry. In 1984 he finished his Ph.D. in Biochemistry at the University of Zurich with the thesis entitled "Characterization of two new inborn errors of metabolism: Gly-Pro-Hyp- Gly-aminopeptidase and GTP cyclohydrolase I deficiency" and in the same year he was named "Oberassistent" and head of Clinical Chemistry and Mass Spectrometry services at the same institution. In the following years he continued his research in tetrahydrobiopterin metabolism and promoted the worldwide screening for tetrahydrobiopterin deficiencies. This period was highlighted by the discovery of pterin-4a- carbinolamine dehydratase deficiency and by molecular characterization of the mild form of dihydropteridine reductase deficiency. Since 1990 he is a head of the Laboratory for Selective Screening of Metabolic Disorders at the University Children's Hospital of Zrich. His research is now focusing on the characterization of tetrahydrobiopterin deficiency variants on both the protein and the DNA levels. In a collaboration with many clinics worldwide he introduced new diagnostic tests and established new treatment protocols for tetrahydrobiopterin and biogenic amine neurotransmitter deficiencies. Besides tetrahydrobiopterin his research interests include nitric oxide metabolism and cardiovascular diseases, folate metabolism, and primary hyperoxalurias. In 1992 an International Database of Tetrahydrobiopterin Deficiencies (BIODEF) was initiated and since 1997. Dr. Blau is a curator of the two HUGO approved online BIODEF and BIOMDB databases. He received his FAMH accreditation in Clinical Chemistry in 1991 and in DNA/RNA testing in 2001, and in 1995 his habilitation in Clinical Biochemistry was approved by the Faculty of Medicine at the University of Zrich. At the same time he became a lecturer in Biochemistry and Cell and Tissue Biology at the University of Zrich. Dr. Blau is author of more than 200 research publications and senior editor of the standard book "Physician's Guide to the Laboratory Diagnosis of Metabolic Disease" which was published in two English and one Chinese editions. He is honorary member of the Italian Society for Pediatrics. Dr. Blau is the fifth winner of the "Horst Bickel Award" which was attributed for his work on the diagnosis of tetrahydrobiopterin deficiencies, particularly the detection and characterization of sepiapterin reductase deficiency, a new inborn error of tetrahydrobiopterin metabolism presenting with neurotransmitters deficiency without hyperphenylalaninemia. |
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Presidential Lecture
May 17 (Friday) Lecture Hall A
| PreL | 17:10¡17:50 |
Chair In Kook Park, Dongguk Univ. |
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Transcriptional Regulation of Hepatitis
B Virus and Superoxide Dismutase Genes Dr. Hyune Mo Rho (Seoul National University, Korea) |
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Dr. Hyune Mo Rho Seoul National University, Korea
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Dr. Hyune Mo Rho graduated from college of Education, Seoul National University in 1961 and received M. S. degree in Plant Biology from Seoul National University in 1963. He went to U. S. A. in 1966 and received his Ph. D. degree in Molecular Biology from Florida State University in 1970. He was postdoctoral and research fellow at the Institute for Molecular Virology, Saint Louses University from 1971 to 1976. Then he moved to the National Cancer Institute, NIH, U.S.A. as a research fellow from 1977 to 1980. In 1980, he joined to the faculty of College of Natural Sciences as an associate professor at Seoul National University, Korea. He is currently a professor of School of Biological Sciences, Seoul National University. Dr. Rho's research in U.S.A was focused on the infection cycles and expression of HIV. In Korea, Professor Rho has studied on the molecular mechanism of hepatitis B virual expression and expresson of human Cu/Zn superoxide dismutase gene. Professor Rho was appointed to an organizing committee member at international symposium for SOD conference in France in 2000. Dr. Rho receives grants from The Korea Science and Engineering Foundation, which is given to advanced leading scientists. He served for president of many academic societies (Microbiology, Virology, and Biochemistry). Professor Rho is a permanant member of the Korean Academy of Science and Technology. |