in Title
  in Authors
  in Institutions
  in Abstract
  in Keywords

  - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
  - Instructions to Authors
   "sample paper download"

  - Preparation of Tables
    and Illustrations


  - Chemical and
    Mathematical Usage,
    Addreviations, and
    Symbols


  - Editorial Board

  - Manuscript submission
   form


 



Article Info.
2004.01.31; 37(1) pp. 93~106
Title

Yeast as a Touchstone in Post-genomic Research: Strategies for Integrative Analysis in Functional Genomics

Authors

Juan I. Castrillo* and Stephen G. Oliver  

Institutions

School of Biological Sciences, University of Manchester, 2205 Stopford Building, Oxford Road, Manchester M13 9PT, UK  

Abstract

The new complexity arising from the genome sequencing projects requires new comprehensive post-genomic strategies: advanced studies in regulatory mechanisms, application of new high-throughput technologies at a genome-wide scale, at the different levels of cellular complexity (genome, transcriptome, proteome and metabolome), efficient analysis of the results, and application of new bioinformatic methods in an integrative or systems biology perspective. This can be accomplished in studies with model organisms under controlled conditions. In this review a perspective of the favourable characteristics of yeast as a touchstone model in post-genomic research is presented. The state-of-the art, latest advances in the field and bottlenecks, new strategies, new regulatory mechanisms, applications (patents) and high-throughput technologies, most of them being developed and validated in yeast, are presented. The optimal characteristics of yeast as a well-defined system for comprehensive studies under controlled conditions makes it a perfect model to be used in integrative, 'systems biology' studies to get new insights into the mechanisms of regulation (regulatory networks) responsible of specific phenotypes under particular environmental conditions, to be applied to more complex organisms (e.g. plants, human).  

Keywords

Functional genomics, Integrative studies, Systems biology, Saccharomyces cerevisiae, Schizosaccharomyces pombe